AIDS and Cancer Specimen Resource (ACSR)

Sylvia Silver,Paige Bracci,Mostafa Nokta,Michael Mcgrath,Jeffrey Bethony,Lisa Rimsza,Johann Schneider,Ashokkumar A Patel,Michael Ittmann

doi:10.5334/ojb.42

Abstract

The AIDS and Cancer Specimen Resource (ACSR) has four regional biorepositories (RBRs) in the United States and one in South Africa. The ACSR is funded by the National Cancer Institute (NCI) of the National Institutes of Health (United States) to support investigators studying HIV/AIDS and HIV/AIDS-associated malignancies. The ACSR inventory includes more than 450,000 annotated HIV-positive biospecimens from over 10,000 individuals and 100,000 HIV-negative controls from approximately 4,250 individuals, reflecting the pre-highly active antiretroviral therapy (HAART) and post-HAART era of the HIV epidemic, as well as selected geographic regions heavily impacted by this global pandemic. Funding statement: The U.S. NIH National Cancer Institute has funded the ACSR since 1994. The present award is UM1CA181255.

Highlights

The ACSR inventory includes more than 450,000 annotated HIV-positive biospecimens from over 10,000 individuals and 100,000 HIV-negative controls from approximately 4,250 individuals, reflecting the pre-highly active antiretroviral therapy (HAART) and post-HAART era of the HIV epidemic, as well as selected geographic regions heavily impacted by this global pandemic
(1) Bioresource Overview Project description The ACSR includes biospecimens from persons with HIV/AIDS who have been diagnosed with a wide spectrum of HIV/AIDS-related diseases and conditions, malignancies
Donor samples and data are obtained from consented individuals through various means including direct recruitment from outpatient clinics and hospitals, donations from AIDS Malignancy Consortium (AMC) clinical trials, and acquisitions from clinical epidemiological studies

Summary

BIORESOURCE PAPER

(1) Bioresource Overview Project description The ACSR includes biospecimens from persons with HIV/AIDS who have been diagnosed with a wide spectrum of HIV/AIDS-related diseases and conditions, malignancies. The ACSR’s mission is to acquire, store, and equitably distribute these samples and associated clinical data to investigators conducting HIV/AIDS-related research. The current inventory includes several large well-annotated special collections, including domestic and sub-Saharan African HIV-related clinical epidemiology studies, AIDS Malignancy Consortium (AMC) clinical trials, and multisite autopsies. Ongoing biospecimen science projects assess the “fit for purpose” of various archival samples, including protein and nucleic acid derivatives, for the evolving needs of HIV/AIDS and the HIV/AIDS malignancy research

Species Human

Findings

(2) Methods Steps