Abstract
This prospective cross-sectional study aimed to evaluate the agreement of two new biometers for measuring ocular biometric parameters in young healthy eyes. Ocular biometric parameters were measured using IOLMaster 700 and OA-2000. Power vector analyses of Cartesian (J0) and oblique (J45) components of corneal astigmatism were performed. The right eyes of 103 healthy volunteers were analyzed. The 95% limits of agreement ranged from −0.03 to 0.03 mm, −0.08 to 0.07 mm, −0.18 to 0.18 diopters (D), −1.09 to 1.16 D, −1.18 to 1.15 D for axial length (AL), anterior chamber depth (ACD), mean keratometry, J0 and J45 respectively, which were all comparable between the two biometers, while significant differences were detected in lens thickness (LT), central corneal thickness (CCT), white-to-white (WTW) and pupil diameter (PD). Predicted intraocular lens (IOL) powers were comparable between the two biometers by Haigis and Barrett Universal II formulas, while not by SRK/T, Hoffer Q and Holladay 2. Excepting CCT, WTW and PD meaurements, IOLMaster 700 and OA-2000 have excellent agreement on ocular biometric measurements and astigmatism power vectors, which provides more options for ocular biometric measurements and enables constant optimization for IOL power calculation.
Highlights
Ocular biometric measurements have been shown to be crucial in many ophthalmic studies and clinical practices
The optical biometric instruments IOLMaster 700 and OA-2000 have been applied in clinical practice, and a few studies have been conducted on these new instruments based on swept-source optical coherence tomography (SS-optical coherence tomography (OCT))
It has been reported that either of instruments provides repeatable measurements with a deeper imaging range, less sensitivity reduction and faster scanning speeds[8,9,10,11], there were no studies comparing the agreement between IOLMaster 700 and OA-2000 on ocular biometric parameters in subjects with transparent lens to date
Summary
Ocular biometric measurements have been shown to be crucial in many ophthalmic studies and clinical practices. Novel non-contact and high-resolution optical biometric devices, such as IOLMaster 700 (Carl Zeiss Meditec AG, Jena, Germany) and the OA-2000 (Tomey, Nagoya, Japan), have been available. Both biometers are based on swept-source optical coherence tomography (SS-OCT), the newest variations of Fourier-domain optical coherence tomography (OCT)[3], in which the interference patterns go through a process known as Fourier transformation allowing all light echoes to be measured simultaneously. The IOLMaster 700 combines SS-OCT with a tunable laser wavelength centering on 1,055 nm (a wavelength varying from 1,035 to 1,095 nm) and a multidot keratometer This device performs optical B-scans (optical cross-section) for measuring the ocular parameters, allowing the visualization of axial anatomical structures as a two-dimensional OCT image and ensuring fine alignment by the presence of the fovea. The present study aims to provide a clinical reference by analyzing the measurements and evaluating the agreements of the axial length (AL) but the anterior segment parameters, including anterior chamber depth (ACD), central corneal thickness (CCT) and lens thickness (LT), keratometry readings (K), white-to-white (WTW) distance, pupil diameters (PD), corneal astigmatism of Cartesian (J0) and oblique (J45) components by power vector analyses, and IOL power calculation between IOLMaster 700 and OA-2000 in healthy eyes for the first time
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