Abstract
The potencies and efficacies of seven agonists at chick α7 nicotinic receptors expressed in Xenopus oocytes were determined by whole cell recording. (+)-Anatoxin-a was the most potent agonist (EC 50 = 0.58 μM) and acetylcholine was the least potent (EC 50 = 320 μM). The rank order of agonist potencies was: (+)-anatoxin-a ⪢ cytisine > (−)-nicotine > (+)-nicotine > DMPP > 1-acetyl-4-methylpiperazine methiodide > acetylcholine. DMPP evoked only very small currents: comparison of maximally effective agonist concentrations showed that DMPP was only one-fifth as efficacious as other agonists. Previously published IC 50 values for rat brain [ 125I]α-bungarotoxin sites show a similar agonist profile, and the identity of homo-oligomeric α7 receptors with native α-bungarotoxin-sensitive neuronal nicotinic receptors is discussed.
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