Abstract
Silver nanoparticles (AgNPs) are among the emerging nanoproducts that have gained increasing interest in the field of nanomedicine due to their unique properties and obvious therapeutic potential in treating a variety of diseases. The authors used a methanol and aqueous fruit extracts of Pseudocydonia sinensis to synthesize AgNPS. To their knowledge, this is the first report where Pseudocydonia sinensis fruit was found to be a suitable plant source for the green synthesis of AgNPs. The AgNPs were characterized by UV-visible spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. Green synthesized Meoh-AgNPs and aqueous-AgNPs were found toxic against S. aureus (KCTC 1916), B. substilis (lab culture), E. coli (KCTC 2441), C. albicans (lab culture), and S. cerevicae (KCCM 1020). MTT assay showed (B16/F10 melanoma cancer cell line) minimum cell inhibition (1.01%) was observed at 0.12mM and maximum cell inhibition (81.85%) at 1mM. Meoh-AgNPs appeared to be more active than aqueous-AgNPs. Furthermore, this green synthesis is a rapid and simple alternative to chemical synthesis.
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