Abstract
To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals. Despite a decline in SCE induction in bone marrow cells in older mice at high mitomycin C concentrations, SCE induction in EAT cells was not significantly affected by the age of the animal. These findings suggest that the aging environment may not play a major role in the diminished SCE induction observed in old cell populations.
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