Abstract
A regioselective synthesis of β‐fluorinated ketones by silver(II)‐mediated ring opening is described. Commercially available AgF2 serves as both an oxidant and fluorine‐atom source. A variety of β‐fluorinated ketones are efficiently prepared from tertiary cyclopropanol precursors, offering a straightforward approach for the introduction of a fluorine atom at a remote site. Selectivity is observed in the site of bond cleavage, which leads to fluorination at the more substituted site. A radical mediated sequential homolytic C–C bond cleavage and C–F bond formation is suggested.
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