Abstract
Classical mantle cell lymphoma (cMCL) is a B-cell neoplasm characterized immunohistochemically by their cluster differentiation (CD)5-positive (CD5+), CD19+, CD20+, CD23−, and cyclin D1+ nature and confirmed genetically by the presence of t(11;14), which results in the overexpression of cyclin D1. cMCL generally presents with adenopathy, spleen, bone marrow involvement, and extranodal sites most commonly the gastrointestinal tract, with a median survival rate of 3 to 5 years.1,2 Leukemic, non-nodal mantle cell lymphoma (L-NN-MCL) is a relatively uncommon subtype of mantle cell lymphoma (MCL), which is generally considered to be indolent.
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