Abstract
In the primary immune response of mice to sheep's red cells rosette-forming cells with aggregated immunoglobulins on their surface appear in the fraction of small lymphocytes in the spleen. These cells effectively incorporate thymidine and can be eliminated in vivo by injecting the mice with large doses of the tritiated base. It can be concluded from the results that rapidly dividing lymphocytes, specifically binding antigen, characteristically have aggregated immunoglobulins on their surface.
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