Effect of polybutylcyano acrylate nanoparticles on primary immune response of mice to sheep erythrocytes

Abstract

The effect of polybutylcyanoacrylate nanoparticles (PBCN) on the primary immune response of mice to sheep erythrocytes (SRBC) was studied by estimating antibody production (hemagglutinins) and rosette-forming cells (E-RFC). The data obtained indicated that the ability of treated mice to establish a specific immune response was markedly impaired when PBCN were administered at high doses prior to antigenic stimulation. The degree of depression was dose-dependent. When PBCN were injected after immunization or on the day of immunization with SRBC, there were no significant differences with the control. Small doses of PBCN given before immunization or shortly thereafter stimulated the primary immune response to SRBC. These data revealed that the inductive phase of primary immune response had been affected preferably by PBCN. The conclusion might be drawn that the specific immune response induced in animals before treatment with PBCN would not be affected by nanoparticles and that they could be used as a drug carrier in chemotherapy.