Abstract
Numerical and analytic calculations of the per cell probability of undergoing malignant transformation utilising realistic estimates of mutation frequencies are shown to be consistent with the proposal that the initiating event of carcinogenesis is the result of mutations causing defective vertical transmission of epigenetic gene silencing and that carcinogenic progression embodies multiple genetic derangements resulting from this, suggesting that the Epigenetic Theory of Cancer Progression provides a satisfactory explanation for the observed hypermutability of malignant tumours.
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