Abstract

Senescence of the immune system is a complex phenomenon that is typically seen as a state of immunological dysregulation and is characterised by impairment of various lymphocyte activities. Ageing is a condition linked to numerous societal changes that can cause psychological stress, which is frequently seen to be beyond our control and can, in some situations, result in clinically meaningful depression. A rising interest in the study of the connections between the immune system and the central nervous system (psychoneuroimmunology) has emerged in recent years. Present objective was to compile the most recent research on the intricate relationships between stress, depression, psychoneuroimmunology, and the effects on aged people. This review discussed the effects of ageing on the mental health of the older population and changes to the HPA axis. The focus shifts to the gut- brain axis and neurodegeneration after that. The dietary impacts of ageing are also explored towards the conclusion. The study's findings emphasise the importance of using a multidisciplinary approach to properly comprehend the intricate connections between psychoneuroimmunology, nutrition, and mental health.

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