Abstract
The performance of young (3–5 months) and aged (20–21 months) Swiss mice on a step-down passive-avoidance task was compared in two separate experimental paradigms. Preliminary shock sensitivity testing demonstrated that response thresholds did not differ significantly between young and aged mice. Aged mice trained on a single-trial step-down procedure demonstrated significant retention deficits compared to young mice at a 24-hr training-testing interval, but not a 2-hr interval. Separate groups of mice were trained to a 180-sec criterion of avoidance and tested daily for retention over 10 days following acquisition training. Aged mice tended to step-down sooner than young animals. These data suggest age-related retention deficits in the Swiss mouse for step-down passive avoidance without significant alterations in shock sensitivity.
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