Abstract
Objectives to analyze the number and sum of diameters of microgliocytes in the precentral gyrus cortex and the corpus callosum of a person in the early adulthood and of an old person and to identify the patterns of neurofilaments expression in these parts of the brain.
 Material and methods. The results of a sectional study of the cerebral cortex in the precentral gyrus and corpus callosum using hematoxylin and eosin staining were analyzed, and an immunohistochemical study was performed using antibodies to neurofilaments. The dead were divided into two groups depending on their age. The group I included 23 men and 27 women in their early adulthood, aged from 23 to 28 years; the group II included 19 men and 25 women of the old age from 75 to 83 years. We examined the number of microgliocytes, the sum of their diameters, and the expression of neurofilament proteins in the tissue.
 Results. Morphometric study of autopsy material showed that in the corpus callosum, as well as in the cortex of the precentral gyrus, there was an age-related statistically significant increase in the number of microgliocytes and the sum of their diameters (p 0.001). We found that the expression of neurofilaments in the cortex of the precentral gyrus is uniform both in the early adulthood and in old age. In the corpus callosum tissue, the age-related neurodegenerative changes are more pronounced: by old age, there is a significant decrease in the expression of neurofilaments with the formation of their rarefaction sites in the areas of microgliocyte clusters.
 Conclusion. The results of morphological study of the precentral gyrus cortex and corpus callosum of two age groups testify that the number and sum of diameters of microgliocytes responsible for the utilization of spent myelin have a certain relationship with age and expression of neurofilaments in the nervous tissue.
Highlights
We examined the number of microgliocytes, the sum of their diameters, and the expression of neurofilament proteins in the tissue
We found that the expression of neurofilaments in the cortex of the precentral gyrus is uniform both in the early adulthood and in old age
In the corpus callosum tissue, the age-related neurodegenerative changes are more pronounced: by old age, there is a significant decrease in the expression of neurofilaments with the formation of their rarefaction sites in the areas of microgliocyte clusters
Summary
Цель – на секционном материале провести сравнительный анализ количества и суммарного диаметра микроглиоцитов в коре предцентральной извилины и мозолистом теле человека в первом периоде зрелого возраста и в старческом возрасте и выявить закономерности экспрессии нейрофиламентов в этих отделах мозга. Проведен анализ результатов секционного исследования коры мозга в области предцентральной извилины и мозолистого тела с использованием окраски гематоксилин и эозин, а также проведено иммуногистохимическое исследование с использованием антител к нейрофиламентам. Определяли количество микроглиоцитов, их суммарный диаметр, а также наличие экспрессии белков нейрофиламентов в ткани. Морфометрическое исследование аутопсийного материала показало, что в мозолистом теле, так же как и в коре предцентральной извилины, установлено возрастное статистически достоверное увеличение количества микроглиоцитов и их суммарного диаметра (p
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