Age and the cascade impact on coronary flow reserve (CFR) and discordance of fractional flow reserve and non-hyperemic pressure ratios (NHPR).

Abstract

Key Points CFR decreases with age because hyperemic flow is reduced. Reduced hyperemic flow affects FFR but not NHPR, contributing to a higher rate of discordance between pressure ratios in the elderly. Using a dichotomous age cut off of 60 years, the impact of age in patients with discordant physiologic indices is minimal.