Abstract
Purpose. To investigate age- and position-related changes of anterior chamber angle anatomy in normal, healthy eyes. Patients and Methods. Thirty subjects were separated into a younger and older cohort. The superior and inferior anterior chamber angles of the eyes were measured in supine and sitting positions by ultrasound biomicroscopy (UBM) with bag/balloon technology. Statistical analysis was used to evaluate positional and age-related changes in angle morphology. Results. In the younger cohort, no location or positional differences in angle anatomy were observed. In the older cohort, the inferior quadrant was significantly narrower than the superior quadrant (P = 0.0186) in the supine position. This cohort also demonstrated an interaction effect between position and location. In the older cohort, the angle was deeper inferiorly while the subject was sitting but was deeper superiorly while the subject was supine. Conclusion. Comparison of positional variations in anterior chamber angle anatomy as measured by UBM has recently become possible. This study found that age-related positional changes in the anterior chamber angle anatomy exist in normal healthy eyes.
Highlights
Ultrasound biomicroscopy (UBM) provides noninvasive high-resolution in vivo imaging of the anterior segment
While anterior tissues are readily visualized by conventional methods, structures posterior to the iris are hidden due to absorption of light by the iris pigment epithelium
Such structures may be undetected by anterior segment optical coherence tomography (ASOCT), given the inability of light to penetrate the iris pigment epithelium
Summary
Ultrasound biomicroscopy (UBM) provides noninvasive high-resolution in vivo imaging of the anterior segment. While anterior tissues are readily visualized by conventional methods (e.g., slit-lamp biomicroscopy and gonioscopy), structures posterior to the iris are hidden due to absorption of light by the iris pigment epithelium. Such structures may be undetected by anterior segment optical coherence tomography (ASOCT), given the inability of light to penetrate the iris pigment epithelium. UBM can be used to image the anterior chamber angle and the ciliary body, peripheral lens, zonules, and the posterior chamber of the eye [1]. UBM has become the current standard for imaging abnormalities of ciliary body position, as are found in plateau iris configuration and annular choroidal effusions
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