Abstract
The sensitive detection of various neurotransmitters is very useful in diagnosing diseases related to the dysfunction of the neurotransmitter system. Surface-enhanced Raman scattering (SERS) is one of the best methods for bio-analyte detection as it provides a molecular fingerprint at a trace concentration level. In this study, Ag-deposited porous silicon (Ag@pSi) was fabricated as a SERS-active substrate via metal-assisted chemical etching and electroless plating methods. Dopamine (DA) and norepinephrine (NE) neurotransmitters were tested as probing analytes. The Ag@pSi substrate demonstrated the sensitive detection of the neurotransmitters (DA and NE) over the wide concentration range (from 10‒6 to 10‒10 M), with a good linearity between the intensity of specific Raman peak and the log-scale concentration. The Ag@pSi substrate also distinguished the individual analytes in a mixture of DA and NE at 10‒8 M, confirming the efficacy of the developed SERS substrate for the selective detection of neurotransmitters.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
