Abstract
Some studies have demonstrated that acrylamide (AA) was correlated with oxidative stress, resulting in physical damage. The jackfruit flake was an immature pulp that contained a high level of antioxidant activity. This study aimed to assess the defensive efficacy of jackfruit flake in AA-induced oxidative stress before and after simulated gastrointestinal digestion. Our results indicate that the total polyphenol content of Jackfruit flake digest (Digestive products of jackfruit flake after gastrointestinal, JFG) was diminished; however, JFG had raised the relative antioxidant capacity compared to Jackfruit flake extract (JFE). Additionally, the results of High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) implied that a proportion of compounds were degraded/converted into other unknown and/or undetected metabolites. Further, by high content analysis (HCA) techniques, JFG markedly reduced cytotoxicity and excessive production of reactive oxygen species (ROS) in cells, thereby alleviating mitochondrial disorders. In this study, it may be converted active compounds after digestion that had preferable protective effects against AA-induced oxidative damage.
Highlights
IntroductionAcrylamide (AA), threatening human health, is widely found in foods
As a potential carcinogen, acrylamide (AA), threatening human health, is widely found in foods.Some studies have reported that AA mainly derives from the Maillard reaction of aspartic acid and reducing sugar at high temperatures [1]
It was concluded that the polyphenol contents of Jackfruit flake were greatly reduced after gastrointestinal digestion, which was consistent with the results for apples [18]
Summary
Acrylamide (AA), threatening human health, is widely found in foods. Some studies have reported that AA mainly derives from the Maillard reaction of aspartic acid and reducing sugar at high temperatures [1]. As far as we know, there is widespread exposure to high amounts of AA from heated food in human daily life. AA has strong carcinogenicity, neurotoxicity, and genotoxicity [2]. Some studies have monitored that AA is absorbed by intestinal cells, increasing the accumulation of intracellular reactive oxygen. The scientific name of jackfruit is Artocarpus heterophyllus Lam., belonging to the Moraceae family
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