AFRICAN'S LEAF (VERNONIA AMYGDALINA) EXTRACT EFFECT FOR TRYGLICERIDE LEVEL ON WISTAR RAT WITH METABOLIC SYNDROME

Abstract

Objective: This study was designed to determine the effect of African's leaf (Vernonia amygdalina) extract towards triglyceride level of Wistar rats (Rattus norvegicus) with metabolic syndrome model. Design and method: The research was laboratory experimental research using pretest- posttest control group design. It included 30 male Wistar rats that were divided into 5 groups of normal control group (KKn), positive control group (KKp), and treatment groups (KP1, KP2, KP3). KKp, KP1, KP2 and KP3 were metabolic syndrome induced, fed with high fat high fructose diet and were given with STZ- Na injection. KP1, KP2 and KP3 were given treament of ethanolic extract of Vernonia amygdalina with dosage 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW respectively. Metabolic syndrome induction were done with high fat high fructose diet for 31 days and injection of STZ-Na on the 28th. Treatment groups got the extract of Vernonia amygdalina for 28 days subsequent to metabolic syndrome induction. The result data of trygliceride level were analyzed using one way ANOVA and Post-Hoc Tukey. Results: There was a significant differences of trygliceride level between day 32th and 61st with p = 0.000 (p < 0,05) on all groups. Decreased level of trygliceride were showed the highest on KP3 with mean different value 28,7476 mg/dL, followed by KP1 with 23,7983 mg/dL, and KP2 with 20,8933 mg/dL. Conclusions: Extract of African's leaf (Vernonia amygdalina) has a significant effect of lowering trygliceride level.