Abstract
We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011–January 2014 in Kimpese, Democratic Republic of the Congo. Cases were confirmed by histopathology, immunohistochemistry, and reverse transcription PCR. All patients were HIV negative. Putative sources for the pathogen were cellar bats and guano fertilizer exploitation.
Highlights
We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011– January 2014 in Kimpese, Democratic Republic of the Congo
We describe an unusual case series of African histoplasmosis in HIV-negative patients in Kimpese, Democratic Republic of the Congo
Because special staining for fungi is unavailable in Kimpese, paraffin blocks were sent to Sheba Medical Center (Ramat Gan, Israel), where control hematoxylin and eosin (HE), periodic acid Schiff (PAS), and Grocott methenamine-silver (GMS) staining were performed
Summary
We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011– January 2014 in Kimpese, Democratic Republic of the Congo. Capsulatum, involves mainly the lungs, African histoplasmosis commonly involves the skin, followed by the bones. It tends to occur more frequently in patients infected with HIV. Few reported cases of African histoplasmosis have been described from the Democratic Republic of the Congo; all were sporadic [3,4,5,6].
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