Abstract
Histoplasma capsulatum: more widespread than previously thought.
Highlights
Overall, nearly 82% of all reviewed cases of histoplasmosis from China were reported from nine provinces through which the Yangtze River flows and where climate conditions are probably favorable for H. capsulatum growth[6]; it is worth noting that 86% of these cases were classified as disseminated, and in 52% of affected patients no underlying diseases were disclosed
Histoplasmosis is an endemic mycosis caused by a dimorphic fungus with two distinct varieties pathogenic for humans: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii
General textbooks of medical mycology when considering the geographic distribution of H. capsulatum var. capsulatum either refer only to “eastern United States
Summary
Nearly 82% of all reviewed cases of histoplasmosis from China were reported from nine provinces through which the Yangtze River flows and where climate conditions are probably favorable for H. capsulatum growth[6]; it is worth noting that 86% of these cases were classified as disseminated, and in 52% of affected patients no underlying diseases were disclosed. Capsulatum either refer only to “eastern United States (Ohio, Mississippi, and St. Lawrence River valleys) and most of Latin America,”[1] or indicate that “isolated cases have been reported from Southeast Asia and Africa.”[2] In this issue of the Journal, Wang and others[3] describe an autochthonous case of disseminated progressive histoplasmosis (DPH) observed in a young human immunodeficiency virus (HIV)-negative Chinese man.
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