African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.

Rachel Martini,Mahteme Bekele Muleta,Brittany Lord,Balasubramanyam Karanam,Engida Abebe,Aisha Jibril Suleiman,Brian Stonaker,Nicolas Robine,Baffour Awuah,Lindsay F Petersen,Upender Manne,Isra Elhussin,Jason White,Kwasi Ankomah,Erica Proctor,Kevin Gardner,Andrea Sboner,Melissa B Davis,John D Carpten,Esther Cheng,Kanika Arora,Princesca Delpe,Michael O Adinku,Ishmael Kyei,Deepa Bedi,Joseph K Oppong,Latoya Jackson,Olivier Elemento,Paula Ginter,Endale Gebregzabher,Yalei Chen,Akanksha Verma,Timothy R Chu,Rick A Kittles,Kofi K Gyan,Lee D Gibbs,Syed A Hoda ,David Nathanson ,Ernest Osei‐Bonsu ,Clayton Yates ,Ernest Adjei ,Jessica Bensenhaver ,Dhananjay Chitale ,Lisa A Newman ,Nigel P Mongan ,Francis Aitpillah ,Zarko Manojlovic

doi:10.1158/2159-8290.cd-22-0138

African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.

Rachel Martini, Mahteme Bekele Muleta + Show 45 more

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https://doi.org/10.1158/2159-8290.cd-22-0138

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Journal: Cancer Discovery	Publication Date: Sep 19, 2022
Citations: 53	License type: CC BY-NC-ND 4.0

Affiliation: Cornell University, University of Georgia, St. Paul's Hospital Millennium Medical College, Tuskegee University, New York Genome Center, Komfo Anokye Teaching Hospital, Henry Ford Health System, University of Alabama at Birmingham, Center for Cancer Research, Columbia University, University of Southern California, Kwame Nkrumah University of Science and Technology, City of Hope, University of Nottingham

#Triple-negative Breast Cancer Biology #Triple-negative Breast Cancer + Show 8 more

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Abstract

Our comprehensive ancestry quantification process revealed that ancestry-associated gene expression profiles in TNBC include population-level distinctions in immunologic landscapes. These differences may explain some differences in race-group clinical outcomes. This study shows the first definitive link between African ancestry and the TNBC immunologic landscape, from an African-enriched international multiethnic cohort. See related commentary by Hamilton et al., p. 2496. This article is highlighted in the In This Issue feature, p. 2483.

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