African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.

Rachel Martini,Mahteme Bekele Muleta,Timothy R Chu,Kanika Arora,Kwasi Ankomah,Nicolas Robine,Paula Ginter,Kevin Gardner,Balasubramanyam Karanam,Latoya Jackson,Engida Abebe,Yalei Chen,Lee D Gibbs,Michael O Adinku,Endale Gebregzabher,Brian Stonaker,John D Carpten,Lindsay F Petersen,Brittany Lord,Ishmael Kyei,Akanksha Verma,Princesca Delpe,Jason White,Joseph K Oppong,Esther Cheng,Isra Elhussin,Upender Manne,Olivier Elemento,Deepa Bedi,Andrea Sboner,Melissa B Davis,Aisha Jibril Suleiman,Kofi K Gyan,Erica Proctor,Rick A Kittles,Baffour Awuah,Jessica Bensenhaver ,Lisa A Newman ,Ernest Adjei ,Syed A Hoda ,Zarko Manojlovic ,Francis Aitpillah ,Dhananjay Chitale ,Nigel P Mongan ,Clayton Yates ,David Nathanson ,Ernest Osei‐Bonsu

doi:10.1158/2159-8290.cd-22-0138

African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.

Rachel Martini, Mahteme Bekele Muleta + Show 45 more

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https://doi.org/10.1158/2159-8290.cd-22-0138

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Journal: Cancer discovery	Publication Date: Sep 19, 2022
Citations: 73	License type: CC BY-NC-ND 4.0

Affiliation: Cornell University, University of Georgia, St. Paul's Hospital Millennium Medical College, New York Genome Center, Komfo Anokye Teaching Hospital, Columbia University, Tuskegee University, Henry Ford Health System, University of Southern California, Kwame Nkrumah University of Science and Technology, Center for Cancer Research, University of Alabama at Birmingham, City of Hope, University of Nottingham

#Triple-negative Breast Cancer Biology #Triple-negative Breast Cancer #African Ancestry #Incidence Of Triple-negative Breast Cancer #Patients Of African Descent #Women Of African Descent #Clinical Outcome In Women #Immunologic Landscape #East Africans #Self-reported Race

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Our comprehensive ancestry quantification process revealed that ancestry-associated gene expression profiles in TNBC include population-level distinctions in immunologic landscapes. These differences may explain some differences in race-group clinical outcomes. This study shows the first definitive link between African ancestry and the TNBC immunologic landscape, from an African-enriched international multiethnic cohort. See related commentary by Hamilton et al., p. 2496. This article is highlighted in the In This Issue feature, p. 2483.

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African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.