AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD.

Abstract

In order to investigate in detail the increase in blood thiamine level after administration of thiamine propyl disulfide, TPD-S35 (outer), and TPD-S35 (inner), and of thiamine-S35 in rabbits, the distribution of S35 in the blood was examined and the following interesting findings were obtained.1. The thiamine part of TPD was shown to be found in large quantities in blood cells, while the majority of S35 was found in plasma after oral or parenteral administration of TPD-S35 (outer).2. S35 was found in the albumin fraction rather than in the globulin fraction of plasma after administration of TPD-S35.3. After parenteral administration of TPD-S35 (inner), S35 was found mainly in blood cells, and extremely poorly in plasma.4. The SH group in blood cells is shown to be involved in the mechanism of the penetration of the thiamine part of TPD into blood cells.5. S35 was increased in blood cells after oral administration of TPD-S35 (inner), though it was less than after subcutaneous injection, whereas the increase in S35 was scarcely noted in blood cells after administration of thiamine-S35. The finding suggests that TPD passes through the intestinal tract without alternation.