Abstract
Anti- SSB La antibody is one kind of antinuclear antibody and is found predominantly in patients with Sjögren's syndrome and systemic lupus erythematosus. SSB La antigen is present in the nucleus as ribonucleoprotein in particle form and is composed of peptide and RNAs. SSB La antigen can be partially purified through several sequential procedures including salt fractionation and ion exchange chromatography. SSB La antigen is capable of binding to 4 RNAs from uninfected KB cells and 6 RNAs from Epstein-Barr virus transformed WiL2 cells. These RNAs can bind to SSB La peptide in vitro and form ribonucleoprotein complexes which could be reprecipitated by anti- SSB La antibody. SSB La associated RNAs are labile and subjected to degradation easily. Anti- SSB La antibody may be a useful probe to investigate the potential role of Epstein-Barr virus involvement in cutaneous pathology.
Published Version
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