Abstract
This study aimed to analyse the pathogenic spectrum and epidemiological characteristics of infectious diarrhea in Yantai City, Shandong Province, China and provide a reference for its prevention and control. A total of 713 stool specimens collected within 3 days of diarrhea onset from January to December 2017 at secondary or higher hospitals in Yantai City were tested for 10 causative pathogens, using real-time polymerase chain reaction (RT-PCR). The top two rotaviruses and norovirus were analysed for typing and geographical distribution. The total positive rate was 46.56% (332/713), and 268 of 713 specimens contained at least one pathogen; 64 had at least two pathogens, accounting for 19.28% of the positive specimens (64/332). The positivity rates of rotavirus (RV), norovirus (NoVs) GI, norovirus (NoVs) GII, enterovirus universal (EV), enteric adenoviruses (EAdV), sapovirus (SaV), astrovirus (Astv), Salmonella (SE), Listeria monocytogenes (LiMo), and Vibrio parahaemolyticus (VP) were 20.06% (143/713), 1.82% (13/713), 12.84% (89/713), 10.66% (76/713), 4.07% (29/713), 0.42% (3/713), 2.38% (17/713), 1.54% (11/713), 1.82% (13/713), and 1.54% (11/713), respectively. Infectious diarrhea showed a high prevalence in young children aged 1-5 years, accounting for 48.6% of the total number of cases. Bacterial diarrhea was predominant in summer, and viral diarrhea was distributed throughout the year, without a significant seasonal pattern. Rotavirus is dominated by G9P, accounting for 81.82%, while norovirus is dominated by the GII type and has diverse characteristics. The aetiology of infectious diarrhea in Yantai is mainly viral, with RV, NoVs, EV, EAdV, and Astv being the most frequent pathogens. Continuous surveillance of infectious diarrhea diseases can help us understand its epidemiological and pathogenic characteristics, thereby taking targeted preventive and control measures in different seasons.
Highlights
Diarrhea is a global public health problem, causing approximately 760,000 child deaths worldwide each year [1]
This study aimed to investigate the pathogenic spectrum of infectious diarrhea and the molecular epidemiological pattern of key causative pathogens in Yantai City, Shandong Province, China in 2017, and to provide a basis for improving relevant preventive measures and reducing the disease burden in this region
From 1 January to 31 December 2017, a total of 713 cases of diarrhea were registered in the comprehensive disease surveillance system in Yantai City, Shandong Province, China
Summary
Diarrhea is a global public health problem, causing approximately 760,000 child deaths worldwide each year [1]. It is classified by aetiology as infectious or non-infectious diarrhea. Long-term surveillance of the pathogenic spectrum composition and epidemiological characteristics of infectious diarrhea can provide a basis for establishing prevention and control strategies and the adoption of targeted preventive and control measures. This study aimed to investigate the pathogenic spectrum of infectious diarrhea and the molecular epidemiological pattern of key causative pathogens in Yantai City, Shandong Province, China in 2017, and to provide a basis for improving relevant preventive measures and reducing the disease burden in this region
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
