Abstract
The objectives of this study were (1) to assess the cardiovascular and regional brain blood flow (rBBF) changes following laryngoscopy and endotracheal intubation (L/I) in hypercarbic, term, neonatal piglets; and (2) to define the modification in these responses by pretreatment with intratracheal lidocaine. Cardiovascular and rBBF changes in 14 hypercarbic, term, neonatal piglets were prospectively studied before and after L/I. The animals were randomly allocated to receive intratracheal lidocaine, or not. Radiolabeled microspheres were used to determine rBBF at baseline, during laryngoscopy, and 2, 7, 15, and 20 min thereafter. Data were analysed using the Neuman Keuls Studentized Range method for multiple comparisons; P < 0.05 was regarded as significant. Baseline rBBF was divided into low (cerebrum) and high (brain stem) flow zones. L/I significantly increased the blood pressure, heart rate, and rBBF. Intratracheal lidocaine prior to L/I significantly reduced the cardiovascular responses and rBBF in th...
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