Aerosol chemotherapy of lung neoplasia.

Abstract

THE administration of anticancer drugs in amounts necessary to obtain a therapeutic response can be associated with severe toxicity. Attempts to circumvent such toxicity have been made and examples of this include intra-arterial infusion chemotherapy and the administration of drugs directly into neoplastic lesions. We wish to suggest a novel extension of such regional cancer chemotherapy and to describe the use of aerosol dosing to confer protective antitumour effects in the lungs of mice carrying certain transplanted tumours.