Aerobic Vs. Resistance Exercise In Igfbp-3 In African American Males And Prostate Cancer Cells Growth

Abstract

The value of aerobic exercise (ex) on health benefits have been well investigated while the benefits of resistance ex have been mostly minimized to that of building muscle and improving performance. Aerobic physical activity has been linked to reducing the growth of prostate tumors by altering function of the insulin-like growth factors. Prostate cancer affects blacks disproportionately, and whether aerobic and resistance ex affects the insulin-like growth factor system similarly is not known. PURPOSE: This pilot study investigated the influence of aerobic ex and resistance ex on the concentration of a substance (insulin-like growth factor binding protein-3 [IGFBP-3]) which attenuates the growth of prostate tumor cells. METHODS: Subjects were 14 sedentary black males 18-29 yrs. Subjects were assigned to groups of an aerobic ex (n = 7) and resistance ex (n = 7). The aerobic ex regime consisted of 7 consecutive days of treadmill jogging at 70% of peak oxygen uptake (VO2peak). The resistance ex regime consisted of 7 consecutive days of strength training the major muscle groups of the upper and lower extremity performing 3 sets of 10 repetitions corresponding to 70% 1 repetition maximum. At the beginning and end of 7 days of aerobic/resistance ex, serum samples of the subjects were incubated with cultures of prostate LNCaP tumor cells. The serum concentration of IGFBP-3 and the relative cell growth were measured. RESULTS: Characteristics of age, body weight and height, VO2peak, % body fat, and maximum leg strength were not significantly different across groups. Baseline serum concentration of IGFBP-3 was similar between the aerobic and resistance ex groups (.056 ±.03 vs..056 ±.01 ng/ml). Further, baseline serum growth rate of the tumor cells were similar between groups (.51 ±.09 vs..50 ±.14%). We observed the tumor cell growth rate after aerobic and resistance ex tended to be lower (11% and 21%), but the difference was not significant. There was a tendency for similar increases in IGFBP-3 after aerobic and resistance ex. CONCLUSION: Aerobic ex vs. resistance ex showed similar clinical directional findings for and increase in IGFBP-3 and decrement in prostate tumor cell growth rate. This study provides evidence suggesting aerobic ex and resistance ex are equally effective in possibly inhibiting the evolution of prostate cancer.