Abstract
www.ClinicalTrials.gov, identifier NCT02253732.
Highlights
Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects ~1% of the population >60 years of age [1]
A prospective study with >36,000 type 2 diabetes (T2D) patients and >108,000 controls, with a 7.3-year follow-up, showed that the presence of T2D increases the risk of PD by 36% [27]
It has been shown that PD patients with T2D have more severe neurological symptoms [28]
Summary
Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects ~1% of the population >60 years of age [1]. Regular exercise has the potential to improve underlying metabolic derangements, including inflammation, mitochondrial dysfunction, and glucose metabolism. Improving muscle functional state in PD by regular exercise could, improve the whole-body functional capacity, slowing down disease progression. This, in turn, may affect the cortical activation of muscles [15, 16], which may be manifested as muscle weakness. Such a reduction in the force generated during muscle contraction is indicative of strength and/or movement speed. There is a proposed relationship between muscle weakness and bradykinesia [17, 18], one of the primary motor symptoms of PD [19]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call