Abstract
Summary Objectives To evaluate liver mitochondrial function and its impacts on fat liver accumulation and the effects of the physical training in cafeteria diet feeding rats. Methods Control (C), sedentary cafeteria diet rats (DIO), and trained cafeteria diet rats (TDIO) accompanied from 21 days old to 120 days old were submitted to body weight and adiposity analysis, glycemic and lipid profile, liver histology, liver mitochondrial analysis (lipid oxidation and phosphorylation capacity). Results DIO presented elevated body weight and adiposity, and aerobic training (TDIO) improved these parameters. TDIO showed reduced triglycerides and LDL-cholesterol and elevated HDL-cholesterol. DIO presented higher fat liver accumulation that was reversed in TDIO. Liver mitochondria from DIO exhibited a higher β-oxidation capacity and an increase in the capacity of oxidizing succinate, with little effects of physical exercise. Our results demonstrated that in DIO, the development of steatosis preceded the establishment of body insulin resistance, which, in turn, has been considered the “first hit” in hepatic steatosis development. These suggest that some intrahepatic events could arise very early in conditions of poor nutrition and probably contribute to the development of NAFLD. Then, our results suggest that starting physical activity just after weaning decreased adverse effects of cafeteria diet on body composition, lipid profile, and liver fat deposition.
Published Version
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