Advantages of the use of polymeric nanoparticles in the treatment of breast cancer: a systematic review

Abstract

Introduction:Breast cancer is responsible for a fifth of the total number of patients diagnosed with malignant neoplasms worldwide. Given the limitations of conventional treatments, studies are advancing to develop new therapies with more specificity and fewer side effects. Thus, the use of polymeric nanoformulations for the delivery of chemotherapeutic agents has been developed for biomedical applications. Objectives:therefore, the study aimed to investigate the advantages and effectiveness of the use of polymeric nanoformulations in drug delivery in relation to conventional therapies in the treatment of breast cancer. Method:bibliographic searches were performed using specific search strings, totaling 12 articles collected. Result:the results showed the effectiveness of the strategy of using polymeric nanoparticles for drug delivery, highlighting the increase in cellular uptake and sustained intracellular retention of drugs incorporated into the nanoparticles. It was evidenced that in addition to the increased efficacy, the safety and delivery of the drug improved. Conclusion:this strategy improved the performance of the drug, having a higher concentration of the active ingredient in the tissues of cancer patients, in addition to increasing the uptake and cellular concentration of the drug, as well as sustaining its intracellular retention, which increases the effectiveness of the treatment, due to its prolongation linked to the slow release and in smaller amounts of the drug.