Advantage of Leakage of Essential Metabolites for Cells.

Jumpei F Yamagishi,Kunihiko Kaneko,Nen Saito

doi:10.1103/physrevlett.124.048101

Jumpei F Yamagishi, Kunihiko Kaneko + Show 1 more

Open Access

https://doi.org/10.1103/physrevlett.124.048101

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Abstract

Microbial cells generally leak various metabolites including those necessary to grow. Why cells secrete even essential chemicals so often is, however, still unclear. Based on analytical and numerical calculations, we show that if the intracellular metabolism includes multibody (e.g., catalytic) reactions, leakage of essential metabolites can promote the leaking cell's growth. This advantage is typical for most metabolic networks via "flux control" and "growth-dilution" mechanisms, as a general consequence of the balance between synthesis and growth-induced dilution with autocatalytic reactions. We further argue that this advantage may lead to a novel form of symbiosis among diverse cells.

Highlights

In microbial communities, diverse species or strains coexist rather than exist as a single fittest type competitively excluding all others, even when limited by a single nutrient [1,2]
Based on analytical and numerical calculations, we show that if the intracellular metabolism includes multibody reactions, leakage of essential metabolites can promote the leaking cell’s growth
We further argue that this advantage may lead to a novel form of symbiosis among diverse cells

Summary

Introduction

Diverse species or strains coexist rather than exist as a single fittest type competitively excluding all others, even when limited by a single nutrient [1,2]. Based on analytical and numerical calculations, we show that if the intracellular metabolism includes multibody (e.g., catalytic) reactions, leakage of essential metabolites can promote the leaking cell’s growth.

Results

Conclusion