Abstract

Acute Liver failure is a serious disease that encompasses multiple etiologies and has high mortality without adequate treatment. Extracellular histones represent a new class of endogenous damage associated molecular patterns (DAMPs) molecules, which play an important role in the initiation and aggravation of liver injury. This article reviews the structure, biological characteristics, origin and cytotoxic mechanism of extracellular histone, and discusses its effect in the pathogenesis of acute liver failure. Key words: Liver failure, acute; Extracellular histones

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