Abstract
Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery.
Highlights
Nano-carriers such as liposomes, polymersomes, niosomes, micelles and polymer-based vesicles can provide an ideal approach for the delivery of therapeutic agents to target sites in the treatment of diseases [1]
They have attracted attention from researchers because of their advantages, e.g., nanocarriers may prolong the half-life of drugs in serum, avoid uptake by reticulo-endothelial systems (RESs) and reduce non-specific adsorption by optimizing its components or building a multi-functional surface
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Summary
Nano-carriers such as liposomes, polymersomes, niosomes, micelles and polymer-based vesicles can provide an ideal approach for the delivery of therapeutic agents to target sites in the treatment of diseases [1] They have attracted attention from researchers because of their advantages, e.g., nanocarriers may prolong the half-life of drugs in serum, avoid uptake by reticulo-endothelial systems (RESs) and reduce non-specific adsorption by optimizing its components or building a multi-functional surface. Melatonin niosome oral gel was formulated in order to overcome the problem of absorption and stability Their pharmacokinetic properties, sleep induction effect and adverse events will be determined in clinical study [12]. Based on these developments and the advantages of niosomes, the structure, components and formulation methods are introduced in this paper and their potential clinical applications are discussed
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