Advances in tissue engineering in the treatment of short bowel syndrome in children

Abstract

Short bowel syndrome(SBS) is a multi-system disease caused by congenital or acquired intestinal diseases, which is the main cause of intestinal failure in children and has high morbidity and mortality in children.Despite decades of experience in the management of short bowel syndrome, current therapy is primarily supportive.Definitive treatment often requires intestinal transplantation, However, bowel transplantation brings new complications and a higher mortality rate.In order to develop novel approaches to the treatment of short bowel syndrome, artificial intestines have come under scrutiny by placing intestinal stem cells on a bioscaffold that has an absorptive surface resembling native intestine and taking advantage of neovascularization to develop a blood supply.This review will explore recent advances in functional epithelium and mesenchymal niche, biomaterials, vascularization, highlighting both success and ongoing challenges in the field. Key words: Tissue-engineering; Artificial intestine; Short bowel syndrome; Children