Advances in solvent based cocrystallization: Bridging the gap between theory and practice

Abstract

A common tactic in materials science and pharmaceuticals is cocrystallization, which synthesises multi-component crystalline materials with unique physicochemical characteristics. The solvent-based method is one of the most popular cocrystallization processes because of its effectiveness and adaptability in creating high-quality cocrystals. This review article covers the solvent-based cocrystallization technique in great detail, emphasizing its methods, applications, and guiding principles. The review methodically examines the important variables and how they affect the development of cocrystals.The review also emphasizes the various practical uses of cocrystallization in the pharmaceutical industry, with a focus on improved medication solubility, stability, and bioavailability.In conclusion, this study offers insightful information about the solvent-based cocrystallization process, including a thorough comprehension of its fundamental ideas, practical applications, and experimental methodologies. For scientists, engineers, and researchers working on the creation of cocrystals for a range of uses, this review is an invaluable resource as it summarizes the state of the art in this area.