Abstract

Acute respiratory distress syndrome (ARDS) , which is notorious for its high mortality rate, is one of the greatest challenges in the field of respiratory and critical care medicine. Mesenchymal stem cell (MSC) , which is readily available and easily expandablein vitro, is considered to be a promising therapy for ARDS. Numerous studies have shown the effectiveness of MSC in the treatment of ARDS. Although the mechanism is not completely understood, differentiation of MSC into alveolar epithelial cells to repair injured lung tissue may be one of the possible mechanisms. Herein, research progress of induced differentiation of MSC into alveolar epithelial cells and its application in the treatment of ARDS is reviewed. Key words: Mesenchymal stem cells; Pulmonary alveoli; Epithelial cells; Acute disease; Respiratory distress syndrome

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