Abstract

Acute respiratory distress syndrome (ARDS) is constitutes a syndrome of acute hypoxemic respiratory failure. The pathologic hallmark of ARDS is diffuse alveolar damage, with injury to both the lung endothelium and epithelium. Promoting the effective repair of alveolar epithelial cells is one of the key therapeutic targets for the treatment of ARDS. With the potential of multi-directional differentiation into endothelial and epithelial, mesenchymal stem cells (MSCs) can restore lung structure and protect pulmonary function. The current review focuses on the mechanisms and regulatory factors that influent MSC-directed differentiation and provide further research directions for the treatment of ARDS. Key words: Mesenchymal stem cells; Differentiation; Acute respiratory distress syndrome

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