Abstract
Abstract Polydiacetylenes (PDAs) have received increasing attention as smart materials owing to their unique optical and electronic properties. PDAs are most commonly synthesized as self-assembled bilayer vesicles via 1,4 addition polymerization. Vesicles are often perceived as closely mimicking the cell membrane, thus functioning as convenient biomimetic platforms. PDAs undergo colorimetric and fluorescent transition in response to external stimuli. Therefore, PDA vesicles can be used in the field of medical detection including bacteria, viruses, proteins, enzymes, etc. In this review, the preparation of PDA vesicle sensing systems and the mechanism of solid phase polymerization are summarized. The applications of PDA vesicle sensing systems in the field of medical detection are introduced here in detail. Besides, the shortcomings and issues to be solved, and future directions are also discussed and prospected.
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