Abstract
CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12). It interacts with CXCR4, and the two are associated with various cancers, as well as other disease states such as coronary artery disease, stroke, inflammation and human immunodeficiency virus (HIV). Antibodies and small interfering RNA (siRNA) have shown the utility of antagonists of CXCR7 in these disease states. Although some small molecules were initially reported as antagonists due to their displayed activity, many function as agonists while still producing the desired pharmacologic effects. A potential reason for this contradiction is that effects may be due to elevated extracellular CXCL12 levels.
Highlights
CXC chemokine receptor 7 (CXCR7) is a G protein-coupled receptor (GPCR), known as atypical chemokine receptor 3 (ACKR3)
Further studies of related 17 mer peptides led to a peptide with GSLW at amino acid positions 1–4 which functioned as an allosteric modulator of CXCR7 that activated signaling to β-arrestin-2
CXCR7 is associated with many disease states such as cancer, coronary artery disease, stroke, inflammatory conditions and human immunodeficiency virus (HIV)
Summary
CXC chemokine receptor 7 (CXCR7) is a G protein-coupled receptor (GPCR), known as atypical chemokine receptor 3 (ACKR3) This receptor was an orphan receptor (RDC1) until 2007 when its two natural ligands, interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (SDF-1 or CXCL12), were identified [1,2]. High expression of CXCR7 is observed in monocytes and maPtuharremBacecuetliclasls[12802]0, ,a1n3d, xtFhOeRrePiEsEaRcRoErVrIeElaWtion between the levels of the protein at the plasma membra2noef 14 and the survival and differentiation of B cells [19]. The Role of CXCR7 in Neurological Conditions The expression of CXCR7 and its ligand CXCL12 are increased post-ischemic stroke [29,30], as CXCL12TahnedeCxXprCeRss7iohnavoefnCeXurCoRp7roatencdtivites eliffgeacntsd[2C9X].CCLX1C2 Ra4reisinalcsroeauspe-drepgouslat-tiesdc,hbeumtiocnsltyroCkXeC[R279,w30a]s, as corCreXlaCteLd12toaanndiCncXrCeaRs7edhsauvrevniveaulrionpmrootuecsteivneeuerfafelcptrso[g2e9n].itCoXr cCeRll4s (ims aNlsPoCusp).-rAengualnattie-CdX, bCuRt7oannlytibCoXdCyR7 waws aads mcoirnriesltaetreeddttoo apnosint-cisrecahseemdicsurravtsiv, aalnidnemnhoaunsecendenueraulropgroegneensiistoarncdelclosg(mniNtivPeCfsu).nActnioann[t4i-3C].XICnR7 mualntitpibleodscylewroassiasd, mthienilsotsesreodf tCoXpCoLst1-i2scohcecmurisc rfarotsm, aanbdluenmhiannaclesdunrfeaucreosgienntehseis CanNdSc, owghniilteivCe XfuCnRct7ion exp[4re3s]s. Silencing of CXCR7 with short hairpin RNA (shRNA) lowered the susceptibility of epileptic mice to seizures
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
