Expression and clinical significance of SDF-1 and CXCR4 in peripheral blood of patients with hepatitis C cirrhosis

Abstract

Objective To detect the expression and clinical significance of stro-mal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in peripheral blood of patients with hepatitis C cirrhosis. Methods From January 2015 to January 2018, 120 patients with hepatitis C cirrhosis in our hospital were selected as the subjects, including 60 patients with compensated hepatitis C cirrhosis and 60 patients with decompensated hepatitis C cirrhosis, and 60 hepatitis C patients without cirrhosis in the same period were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of SDF-1 and CXCR4 in peripheral blood; the correlation between SDF-1 and CXCR4 expressions in compensated cirrhosis and decompensated cirrhosis patients was analyzed. Results The expression levels of SDF-1 and CXCR4 in peripheral blood samples of patients with decompensated cirrhosis of hepatitis C were significantly higher than those of patients with compensated cirrhosis of hepatitis C (P<0.05); the expression levels of SDF-1 and CXCR4 in peripheral blood samples of patients with compensated and decompensated cirrhosis of hepatitis C were significantly higher than those of control group (P<0.05); the expressions of SDF-1 and CXCR4 in peripheral blood of patients with compensated and decompensated cirrhosis of hepatitis C were positively correlated (r=0.684, P<0.05, r=0.765, P<0.05). Albumin (AlB) level in peripheral blood of cirrhosis group was significantly lower than that of control group (P<0.05); alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), while fasting insulin (FINs) and interleukin (IL)-6 in cirrhosis group were higher than those of control group (P<0.05); SDF-1 level and CXCR4 level were positively correlated with AlB, FINs and IL-6 (P<0.05); multiple regression analysis showed that FINs, IL-6, SDF-1 and CXCR4 were risk factors for hepatitis C cirrhosis. Conclusions The levels of SDF-1 and CXCR4 in peripheral blood of patients with hepatitis C cirrhosis increased, and the levels of SDF-1 and CXCR4 in peripheral blood were positively correlated, suggesting that they may be involved in the regulation of the occurrence and development of hepatitis C cirrhosis. Key words: Chemokine CXCL12; Receptors, CXCR4; Hepatitis C; Liver cirrhosis