Abstract
AbstractAt present, therapeutics for the diseases of central nervous system (CNS) are complicated by the presence of the blood‐brain barrier (BBB). The BBB maintains intracranial homeostasis and facilitates brain‐body communications, but hinders the effectiveness of drug‐delivery systems based on nanoparticles (NPs). Great efforts have been devoted to the imprvement of NP‐based brain delivery over the past decades. In addition to chemical modifications, biomimetic technologies such as cell membranes or neurotropic viruses camouflage, immune cells or extracellular vesicles (EVs) loading are promising candidates to make NPs ideal vehicles. This review summarizes the characteristics and transport mechanisms of BBB, and the recent advances in biomimetic technologies as well as administration methods that enhance the BBB penetration and targeting capabilities of NPs.
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