Abstract
Time reversal acoustics (TRA) is one of the most efficient methods of ultrasound focusing in heterogeneous composite biological media, especially inside reverberating cavities, such as the skull. In this talk, we will overview several recently developed therapeutic applications of TRA focusing of ultrasound including enhanced drug delivery to brain tumors, generation of focal regions of complex shape tailored to the geometry of the target lesion and TRA dynamic focusing, that allows to maintain the constant acoustic intensity in the focus regardless the variation of acoustical parameters of the media. We are currently developing several new medical applications of TRA, such as remote charging of batteries in internal implants and leadless energizing deep brain stimulators, which are based on the possibility to remotely generate an electrical signal in tissue using TRA principles. These applications employ a TRA focusing system with wireless electromagnetic feedback from the tiny implanted piezotransducer acting as a beacon. The acoustic energy is accurately focused at the piezotransducer generating required electrical signal while providing minimum exposure of surrounding tissues to ultrasound energy. Possibility of remote generation of electrical signals in tissue with amplitudes reaching tens of volts was demonstrated. [Work supported by NIH R21 CA164935-01.]
Published Version
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