Advanced thermo-mechanical analysis in the magnetic hyperthermia

Abstract

In magnetic hyperthermia, the spatial distribution of the magnetic nanoparticles (MNPs) inside a malignant tissue, after ferrofluid injection influences significantly the therapeutic temperature field. The inclusion of any intra-tumoral pressure as a result of ferrofluid injection modifies considerably the MNP distribution within the tumor volume. We show that this effect has crucial importance in the magnetic hyperthermia analysis. The temperature field can be controlled by the infusion parameters such as: (i) the ferrofluid infusion rate and (ii) the needle gauge size of the syringe. This paper describes the temperature field within a malignant tissue as a function of the infusion parameters. The local displacements of the tissue during the ferrofluid infusion process were considered. The therapeutic temperature field developed by the magnetite particles when an external magnetic field was applied depends strongly on the elastic parameters of the malignant tissue. The analytical model developed in this paper provides the optimum dosage of the magnetite which has to be injected within a soft malignant tissue with a large size, to achieve the hyperthermic temperature. An analysis of the spatial MNP distributions and their heating in the linear relaxation theory was done for different ferrofluid infusion parameters.