Abstract
Background: Antibiotics are considered important and integral parts of modern life, and are widely used for treating human and animal illnesses, in medicine and veterinary medicine. However, they can cause environmental pollution and may lead to increased bacterial resistance even at low concentrations. Methods: In this study, Ampicillin degradation from β-lactam antibiotic family was studied, using a surface methodology consisting of ultraviolet radiation (254 nm) and H2O2 oxidation process in an 8-watt Pyrex reactor. The variables used included the reaction time (30-60 min), Ampicillin concentration (5-25 mg/l), H2O2 concentration (5-25 mg/l), and pH range of 3-9 at three alpha levels of -1, 0 and +1. Results: The data were analyzed by the analysis of variance test (ANOVA), while the validity was evaluated using regression coefficients. The optimum condition for Ampicillin degradation followed a linear model, at a 60-min. reaction time and pH 3, the Ampicillin (5mg/l) and hydrogen peroxide (25mg/l) provided the maximum antibiotic removal efficiency (82%). Conclusions: The results suggest a positive and significant effect for the antibiotic concentration and a negative effect for the pH. The Ampicillin concentration with a coefficient of 8.91 had the highest impact on the efficiency of the removal process. Therefore, antibiotic pollution in the environment can be reduced through the UV-H2O2 process, so as to protect human health from the associated hazards.
Highlights
A mpicillin with a chemical structure ofC16H19N3O4S and a molecular weight of 41.349 gr/mol is a β-lactam antibiotic, derived from amino-penicillinic acid.It is widely used in the treatment of numerous infections against beta-lactamase producing bacteria of both Gram-negative and positive species
The data were analyzed by the analysis of variance test (ANOVA), while the validity was evaluated using regression coefficients
The Ampicillin molecules were exposed to ultraviolet light and hydroxyl radicals of H2O2, such that its removal was made possible ranging from 44% to 82%
Summary
C16H19N3O4S and a molecular weight of 41.349 gr/mol is a β-lactam antibiotic, derived from amino-penicillinic acid It is widely used in the treatment of numerous infections against beta-lactamase producing bacteria of both Gram-negative and positive species. Antibiotics are poorly absorbed or decomposed in the human body, and most of them or their metabolites are excreted through urine and feces, and enter the public sewer systems [3] If these materials are not removed during conventional wastewater treatment, they will enter public water resources [4]. Antibiotics are considered important and integral parts of modern life, and are widely used for treating human and animal illnesses, in medicine and veterinary medicine They can cause environmental pollution and may lead to increased bacterial resistance even at low concentrations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
