Abstract
Background. The quantification of directed interactions within the brain and in particular their time courses are of highest interest for the investigation of epilepsy. The underlying coordinated neuronal mass activities span functionally diverse and structurally widely distributed cortical and subcortical brain regions, i.e. dynamic, distributed epileptic network can be assumed possibly not fitting in the concept of linearity. Consequently, nonlinear, time-variant, and directed connectivity and synchronization analysis could be helpful to understand processes contributing to the seizure onset and propagation.
Highlights
The quantification of directed interactions within the brain and in particular their time courses are of highest interest for the investigation of epilepsy
We investigated the EEG recordings of 18 children with temporal lobe epilepsy (TLE) obtained during presurgical evaluation performed at the Vienna pediatric epilepsy center following a standard protocol
The reason is that the diagonal entries of the parameter matrices Ar are by far higher than the off-diagonal entries
Summary
The quantification of directed interactions within the brain and in particular their time courses are of highest interest for the investigation of epilepsy. Nonlinear, time-variant, and directed connectivity and synchronization analysis could be helpful to understand processes contributing to the seizure onset and propagation. CCM is applied to the EEG of 18 children with temporal lobe epilepsy (TLE), i.e. directed interactions within EEG activity and within specific components of EEG activity (d-activity and a-activity) are investigated. Advanced nonlinear CCM approach was able to uncover time pattern of nonlinear interactions thereby possibly contributing to the further understanding of complex behavior of the brain during TLE. The detection and quantification of directed (causal) interactions within the brain and their time courses are of highest interest in neuroscience in general and in particular for the investigation of epilepsy. The mesial TLE (mTLE) seizure is most probably preceded by a state of enhanced excitability [2]
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