Abstract
DNA methylation, one of the main forms of epigenetics, plays an essential role in ontogeny. Recently, a large quantity of reviews have reported that aberrant DNA methylation exists in different genes of infertile male. This review mainly introduces aberrant DNA methylation on imprinted genes (including H19, FAM50B, GNAS, MEST, KCNQ1OT1, SNRPN) and other related genes (including P16, LINE-1, MTHFR, SLC9B1, DDR1) which influence sperm quality (including sperm count, motility and morphology) in different degrees, leading to male infertility. Thus, the detection on DNA methylation of sperm specific genes might become a new methods for assistant diagnosis on male infertility. Key words: Semen quality; DNA methylation; Male infertility; Epigenetics
Published Version
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