Abstract
ABSTRACTIntroduction: Stem cells obtained from the pulp of human deciduous teeth are highly proliferative and plastic multipotent cells, which makes them a relevant model of stem cells, applied in several biomedical areas, with different purposes. Objective: Based on a brief review of the literature, the present work intends to present from conceptual aspects about stem cells, classifications, potential (in vitro and in vivo) applications in dental practice, cell culture, cryopreservation and its importance, ethical and regulatory aspects, as well as the role of the dental surgeon as the endorser responsible for the entire clinical stage that involves the process of collecting stem cells obtained from dental pulps for cryopreservation, with a view to using them under appropriate conditions, in accordance with scientifically proven and justified good laboratory and clinical practices.
Highlights
Stem cells obtained from the pulp of human deciduous teeth are highly proliferative and plastic multipotent cells, which makes them a relevant model of stem cells, applied in several biomedical areas, with different purposes
Over the past 50 years, we have increased our life expectancy, worldwide, by approximately 30 years.[1]. Much of this is due to small changes in habits and major scientific and clinical advances that have enabled the implementation of increasingly effective prevention, control and treatment measures for so-called infectious diseases. In those places where such measures have been successfully established, considering the socioeconomic and cultural aspects involved, these diseases today account for about 5% of the indices mortality.[2]
The stem cells present in the dental pulps are classified as mesenchymal, due to their ectomesenchymal embryonic origin, which gives them the ability to differentiate into a large number of specialized cells in the human body, such as bone, cartilage, muscle, neuronal cells, cardiac, pancreatic, among others
Summary
Stem cells obtained from the pulp of human deciduous teeth are highly proliferative and plastic multipotent cells, which makes them a relevant model of stem cells, applied in several biomedical areas, with different purposes. Objetivo: A partir de uma breve revisão da literatura, o presente trabalho pretende apresentar desde aspectos conceituais acerca das células-tronco, classificações, potenciais aplicações (in vitro e in vivo) na prática odontológica, cultivo celular, criopreservação e sua importância, aspectos éticos e regulatórios, bem como o papel do cirurgião-dentista como homologador responsável por toda a etapa clínica que envolve o processo de coleta das células-tronco obtidas a partir de polpas dentais para criopreservação, com vistas ao uso em condições adequadas, em acordo com as boas práticas laboratoriais e clínicas cientificamente comprovadas e justificadas.
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