Abstract
The following article presents a method for obtaining molecularly imprinted polymers (MIPs) dedicated to trans-chalcone (TC) and 2′,4′-dihydroxy-3-methoxychalcone (DHMC). The synthetic protocol optimized with a choice of the most suitable functional monomer led to the synthesis of MIPs and their non-imprinted equivalents (NIP) performed via direct polymerization or on the surface of magnetite nanoparticles. The characterized materials were investigated for adsorption isotherms of TC and DHMC, which led to satisfactory values of maximal adsorption capacity, reaching 131.58 and 474.71 mg g−1, respectively. Moreover, all the polymers were studied for the adsorption kinetics and the selectivity towards four structurally different chalcones, which proved the proper selectiveness towards the template molecules. Also, the kinetic profiles of chalcones' adsorption on the synthesized MIPs showed a quasi-plateau reached already after 2 hours, indicating high sorption effectiveness. The studies involved the use of various analytical techniques, which afforded a comprehensive and reliable description of the materials' adsorption efficacy. It was found that the materials successfully bind the MIP-complementary analytes and also structurally similar chalcones, with slightly lower intensity.
Highlights
Discovering and designing of biologically active molecules exhibiting multitherapeutic effects is still of great interest
The synthetic protocol for obtaining the designed chalconeimprinted molecularly imprinted polymers (MIPs) and their magnetic equivalents was based on the standard two-step process involving non-covalent imprinting, followed by a formation of a polymeric net
BMIP and BNIP values correspond to the amount of TC adsorbed on the particular MIPs and nonimprinted equivalents (NIP), respectively
Summary
Discovering and designing of biologically active molecules exhibiting multitherapeutic effects is still of great interest. Among a plethora of molecules proved to be efficient agents in various diseases' treatment, chalcones are very attractive candidates for clinical applications. Chalcones have been found to naturally occur in many species of plants, vegetables, and fruits, the greatest amounts of chalcone and its derivatives have been isolated from families of Leguminosae (peas and beans), Asteraceae (e.g. asters, daisies, or sun owers), and Moraceae (e.g. mulberry, jackfruit, or g).[2] Up to now, chalcones have been postulated for multiple therapeutic effects, especially anticancer, antiin ammatory, antioxidant, antitumor, anti-bacterial, antiviral, and anti-fungal activities.[3,4,5,6,7,8] several chalcone-
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