Abstract
In the present work, the behavior of mixed drug–surfactant systems has been studied by surface tension measurements. The drug used in this work is adiphenine hydrochloride (ADP) and the surfactants are of m-s-m type geminis, i.e., alkanediyl-α,ω-bis(dimethylalkylammonium bromide), with m = (14, 16), s = (4, 5, 6), and conventional alkyltrimethylammonium bromides (CTAB, TTAB). The excess surface concentration (Γ max ) increases and the minimum head group area at the air/water interface (A min) decreases with increasing concentration of surfactant in the drug solution. Both the critical micelle concentration (cmc) and ideal cmc (cmc*) values decrease with mole fraction of surfactants. Also, the cmc values are lower than cmc*, indicating attractive interactions are present in the mixed micelles. The mole fractions of surfactant in the micelles $$ \left( {X_{1}^{m} } \right) $$ and monolayers $$ \left( {X_{1}^{\sigma } } \right) $$ , as well as the respective interaction parameters ( $$ \beta^{m} $$ , $$ \beta^{\sigma } $$ ), indicate that monolayer formation is easier than micelle formation due to the rigid hydrophobic part of the drug.
Published Version
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