Abstract
Background: ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of Cushing's syndrome (CS), which is characterized by massive bilateral nodular enlargement of adrenal glands and hypercortisolism in the presence of suppressed ACTH levels. Case: A 53 year-old woman with a 5-year history of hypertension was referred to our hospital for further evaluation of bilateral adrenal tumors with macronodules, which were detected by computed tomography. She presented with a weight gain of 3 kg over the previous 6 months and pitting edema. Endocrinological data of the patient showed ACTH-independent hypercortisolemia. CS due to AIMAH was suspected. She underwent simultaneous bilateral laparoscopic adrenalectomy. The histopathological analysis confirmed the diagnosis. She was on cortisone acetate (37.5mg per day) replacement therapy postoperatively. No hyperpigmentation was present and she was being well. Her weight declined gradually and her blood pressure was controlled better with less doses of antihypertensive agents during follow-up. Conclusion: AIMAH is an unusual type of Cushing's syndrome. Bilateral adrenalectomy with subsequent steroid replacement is the treatment of choice in patients with AIMAH and CS.
Paper version not known (Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have